Certain type of fat could help humans lose weight
Oct. 2, 2013 — A diet high in a certain type of fat may actually increase metabolism, according to recent research by Texas Tech University nutrition scientists.
Share This:
After studying genetically modified mice, the discovery could lead to supplements and a diet regime that will increase metabolism and decrease muscle fatigue in humans. The research was published in the peer reviewed journal, The Journal of Lipid Research.
Chad Paton, an assistant professor of nutritional biochemistry in the Department of Nutrition, Hospitality and Retailing, said he and colleagues were curious why skeletal muscles of obese people contained a certain type of enzyme that breaks down saturated fats. To test what that enzyme did, Paton's lab and colleagues from the University of Wisconsin -- Madison genetically modified mice so that their muscles would constantly produce the enzyme.
"We used a transgenic mouse model, and we took the gene that makes the enzyme that's not normally expressed and took away it's regulation to make it active all the time," Paton said. "What we found in those animals is they had a hypermetabolic rate compared to the wild mice, increased energy consumption and greatly increased these animals' exercise capacity."
The enzyme, called SCD1, converts saturated fat into monounsaturated fat, which is easier to metabolize. The liver will produce this enzyme depending on the fat content of the food consumed, he said. Fatty adipose tissue produces it all the time as a way of regulating itself.
Only in heavily exercised muscle tissue or in the case of obesity does skeletal muscle produce the enzyme, he said.
After looking at skeletal muscles of the genetically modified mice compared to that of the wild mice, Paton and his team discovered higher levels of polyunsaturated fats, particularly linoleic acid, gotten only through diet.
Higher levels of linoleic acid could only mean one thing -- the modified mice were eating more food. But Paton's team found that the modified mice weighed less than the wild mice. On top of that, their ability to exercise increased.
"We found in the genetically modified animals that they had a hypermetabolic rate," he said. "They were increasing their energy consumption, and they experienced greatly increased exercise capacity. For example, on the exercise wheels, normal mice fatigue after 7 to 10 minutes. These genetically modified animals wouldn't fatigue for about 70 minutes. So they were running a lot longer. Sedentary mice looked more like exercise-trained mice. That really made us look in a lot more detail what was happening in the skeletal muscle." By looking at the muscle tissues, Paton and his team members discovered a trend.
More of the SCD1 enzyme and a greater appetite by the mice meant more linoleic acid in the tissues. The linoleic acid switched on part of the muscle cell's DNA that encouraged the cells to make more mitochondria and to turn on a protein that encouraged the cell to burn off excess energy from the extra food as heat -- a process called uncoupling.
Humans store unused energy as fat, Paton said. And while that helped our ancestors survive, it can lead to obesity for some people in today's world of plentiful food.
While genetically modifying humans isn't an option, Paton said this experiment could hold useful information for supplementing human diets to achieve the same results.
"That's where we have taken our research from this," he said. "You can't change the human genome, but that gives us insight if you could activate the same part of the DNA in human in skeletal muscles that burn off excess energy as heat instead of storing it. Perhaps it's a supplement people could take that will turn on the cells' metabolic machinery burn off energy and increase mitochondria."
Welcome to SUV System Ltd!
SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.
We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.
SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com
Electronic Components distributor:http://www.suvsystem.com
Connectors Distributor:http://www.suvsystem.com/l/Connectors-1.html
IC Distributor:http://www.suvsystem.com/l/IC(Integrated-Circuits)-1.html
LED Distributor:http://www.suvsystem.com/l/LED-1.html
Capacitor Distributor:http://www.suvsystem.com/l/Capacitor-1.html
Transistor Distributor:http://www.suvsystem.com/l/Transistors-1.html
Resistor Distributor:http://www.suvsystem.com/l/Resistors-1.html
Diode Distributor:http://www.suvsystem.com/l/Diodes-1.html
SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc
we are focus on the following fields,and hope we can help you.
ELPIDA IC AD IC Chip Inductors Capacitor TOSHIBA Diodes LED part chip Filter saws LITTELFUSE Diodes Resistor Networks INTERSIL IC Rectifier Diodes Thick Film Resistors Atmel IC Fairchild Semiconductor Transistors ST Transistors TDK IC Freescale Semiconductor Resistor Arrays Fleld Effect Transistors ROHM Resistors Microchip IC Voltage Regulators Transistors PANASONIC Resistors MAXIM IC Electronic News IDT IC Ligitek LED ST Diodes Transistors Bipolar Transistors ALTERA IC Zener Diodes TI IC Discrete Semiconductor Transistors Infineon Technologies Transistors AVX Resistors PANASONIC Low Ohmic Resistors Civil IC Thin Film Resistors
http://www.suvsystem.com/a/6368.aspx
No comments:
Post a Comment